Catherine Zeta-Jones and Michael Douglas announced their separation after 13 years of marriage.

The couple, who were together since 1999 and have two children together, issued a statement saying that they are taking time to “evaluate and work on their marriage.”

Reports suggest that the split was initiated by Zeta-Jones after Douglas revealed that his throat cancer was caused by the human papillomavirus (HPV), contracted through oral sexual contact.

Douglas had previously hinted that his oral cancer was caused by something he “did to myself,” but did not specifically mention HPV.

The revelation reportedly came as a shock to Zeta-Jones, who is said to have been upset that Douglas had contracted the virus before they met. It is not clear when Douglas was infected with HPV, but the virus can lie dormant for many years before causing symptoms.

HPV is a common virus that is spread through sexual contact, and most people who are sexually active will contract it at some point in their lives.

In most cases, the body’s immune system is able to clear the virus on its own, but in some cases it can cause cancer or other health problems.

Douglas has been open about his battle with cancer, and has credited early detection and aggressive treatment with saving his life.

He was first diagnosed with stage 4 throat cancer in 2010, and has undergone chemotherapy, radiation, and surgery to remove the tumor.

Despite their separation, Zeta-Jones and Douglas remain committed to co-parenting their children and maintaining a positive relationship.

In a recent interview, Douglas spoke about the importance of nurturing love in a relationship, saying that “true love takes work” and “has to be nurtured.”

The couple’s split comes as a surprise to many fans, as they have always been considered one of Hollywood’s most solid and successful couples. Zeta-Jones, a Welsh actress, and Douglas, an American actor, met on the set of the film “Traffic” in 1999 and were married the following year.

They have two children together, Dylan Michael, born in 2000, and Carys Zeta, born in 2003. Zeta-Jones has been open about her struggles with depression and bipolar disorder, and has credited Douglas with supporting her through her darkest times.

The couple’s separation is the latest in a string of high-profile celebrity splits, including the recent divorces of Kim Kardashian and Kanye West, and Johnny Depp and Amber Heard.

It remains to be seen whether Zeta-Jones and Douglas will be able to work through their issues and save their marriage, or if they will join the ranks of Hollywood’s most famous divorces.